Abstract

Article info Vol. 6  No. 4   pp.  79 ~ 83
Title Specific Binding and Catalytic Activation of the MAPK-MKP Complex
Authors Myeongbin Kim and Seong Eon Ryu*
Institutions Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04673, Republic of Korea *Correspondence: ryuse@hanyang.ac.kr
Abstract Mitogen-activated protein kinases (MAPKs) are one of the most important enzymes in various cellular activities, and the MAPK signaling pathway is implicated in many disorders. MAPK phosphatases (MKPs) are regulators that contain a MAPK-binding domain (MBD) for MAPK recognition, and a catalytic domain (CD), for dephosphorylation and inactivation of MAPKs. Due to their crucial role in regulating the MAPK pathway, MKPs are regarded as a potential drug target in various diseases. Attempts have also been made to regulate the MAPK pathway by reducing the MKP activity. For drug development, it is important to understand the key features of MAPK-MKP complex formation. This review summarizes the studies on MAPK-MKP complexes, mainly focusing on their selective recognition and catalytic activation.