pISSN 2288-6982
eISSN 2288-7105




BioDesign 2021; 9(3): 47-50

Published online September 30, 2021

© Korean Society for Structural Biology

Accurate protein structure prediction: what comes next?

Chaok Seok1,2,*, Minkyung Baek3, Martin Steinegger4, Hahnbeom Park3, Gyu Rie Lee3 and Jonghun Won2

1Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea
2Galux Inc., Seoul 08738, Republic of Korea
3Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
4School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea

Correspondence to: *

Received: August 4, 2021; Revised: August 20, 2021; Accepted: August 20, 2021


Protein structure prediction has become extremely accurate, and its results are now comparable with those of experimental methods for a large number of proteins. However, there remain some technical hurdles to clear before the current structure prediction tools can be directly applied to a wide range of biomedical problems. New perspectives on future developments in the area of structure prediction and its biomedical applications are presented.

Graphical Abstract